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Stroke
A
stroke or cerebrovascular accident (CVA) occurs when brain tissue
is damaged. This can occur two different ways. In an ischemic stroke
one of the arteries in the brain becomes blocked. When this happens,
part of the brain tissue does not receive the flow of blood it needs
to function and survive. The death of that tissue is the result.
This type is more common. Or, in a hemorrhagic stroke one of the
arteries in the brain leaks or bursts. The blood seeps into the
brain tissue. As a result, the affected brain tissue dies. A transient
ischemic attack (TIA) is a temporary or mini stroke of the ischemic
type. TIAs result when there is a temporary disruption in blood
flow to the brain tissue. TIAs are extremely important warning signs
for stroke and should not be ignored. Most ischemic strokes and
TIA’s are a result of atherosclerosis, or plaques, in the
carotid artery, the main artery to the brain.
In western countries,
stroke is a leading cause of death, and is the second most common
neurological disorder after Alzheimer’s disease. In the United
States, stroke is the third leading cause of death, despite a general
decline in the incidence of stroke in the last 30 years.
Stroke rates increase in a stepwise fashion with age. Tobacco use
imparts a significant risk of stroke that is correlated to usage.
Heavy smokers have twice the relative risk of stroke compared to
light smokers, and the risk of stroke is significantly reduced within
2 years of smoking cessation, with a return to baseline at 5 years.
Hypertension and systolic blood pressure, diabetes, male gender,
and high cholesterol are additional risk factors that have been
shown to impart an elevated risk of stroke. Similar to recent work
in the study of heart disease, inflammation has been shown to be
associated with an increased risk of carotid atherosclerosis. Increased
awareness of other risk factors (heart disease, AIDS, recreational
drug abuse, heavy alcohol consumption, family history of stroke)
has reduced the incidence of strokes. Elevation of the blood homocysteine
level is also a risk factor for stroke. A previous stroke makes
individual patients more susceptible to further strokes.
Symptoms
The clinical presentation
of stroke is often subtle and varied. Onset is usually sudden. Often
there will problems with movement on one side of the body, starting
at one point such as an arm and travelling to other areas. Problems
with speech are usually the most obvious signs. Dysarthria is a
disturbance in articulation of speech and is caused by paralysis
or incoordination of muscles used for speech. Dysarthric speech
is often slurred. Repetition of simple phrases may identify subtle
cases. In contrast, aphasia is caused by a disturbance in processing
language (either written or spoken) and can be receptive (difficulty
in comprehension), expressive (difficulty in communicating thoughts),
or both. Both can happen. Confusion, vertigo, problems with vision
may occur, with weakness. Concomitant complaints such as headache,
vomiting, or recent trauma may be present. Symptoms of TIA’s
may last from seconds to minutes, and then no after effects are
noticed.
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Diagnosis
and Pharmaceutical Interventions
There are several
methods of helping to make the diagnosis of a stroke or TIA. A very
specific neurological examination performed by the health care practitioner
can help to locate which part of the brain that is affected. The
basic neurologic assessment can be broken down into six major areas:
- level of consciousness
- visual assessment
- motor function
- sensation and
neglect
- cerebellar function
- cranial nerves
Many of these tests
may seem rather silly, such as walking on the tip toes, but each
has a specific function. Imaging studies may also be used, as a
CT (computerized tomography) can differentiate bleeding inside the
brain from ischemia. Evaluation of heart function is usually administered
as well, to identify a heart attack. Blood tests that may be helpful
include a complete blood count with platelet count, coagulation
studies, and toxicologic screen. A toxicologic screen for cocaine
or amphetamine use should be obtained in patients with either ischemic
or hemorrhagic stroke in which substance abuse is suspected, particularly
young adults with stroke.
When a diagnosis
of a stroke has been made medications are usually initiated right
away. Anticoagulation drugs that increase the flow of the blood
to the areas of the brain (when the condition is not caused by a
haemorrhage) can reduce the incidence of long term neurological
damage. If the stoke has caused a loss of consciousness, medications
may need to be given by IV, as well as the basics such as fluids
and electrolytes. Long term management usually includes some form
of anticoagulation therapy, such as taking a small amount of aspirin,
a known blood thinner, every day.
Hemorrhagic stroke
must be identified before therapy is given as agents that thin the
blood are contraindicated. Surgery may be necessary in those cases.
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Lifestyle
and Dietary modifications
Exercise reduces
the risk of stroke according to most studies. The benefits of exercise
are probably due to its effects on body weight, blood pressure,
and helping to maintain a healthy blood sugar. It also reduces obesity,
which has been shown to increase risk of stroke in most studies.
Excess abdominal fat (central obesity) appears to be more directly
linked to increased risk of stroke, compared with fat accumulation
in the thighs and buttocks. While losing weight and keeping it off
is difficult for most people, normalizing weight with a healthful
diet and exercise program is one of the best ways to reduce the
risk of many diseases, including stroke.
Having one or two
drinks per day has lowered stroke risk in most studies, but some
believe that even light drinking leads to an increased risk of stroke.
Regular heavy drinking or binge drinking, however, has consistently
raised the risk of suffering a stroke by increasing blood pressure
and causing heart muscle abnormalities and other effects.
Smoking is associated with a significantly increased risk of stroke.
Even secondhand smoke puts non-smokers at increased risk.
Diets high in fruit
and/or vegetables are associated with a reduced risk of stroke,
according to most studies. In a large preliminary study, cruciferous
and green leafy vegetables, as well as citrus fruit and juice, conferred
the highest degree of protection. Because it is not clear which
components of fruits and vegetables are most responsible for the
protective effect against stroke, people wishing to reduce their
risk of stroke should rely primarily on eating more fruits and vegetables
themselves, and having a healthy diet, rather than taking supplements.
There is an association between diets low in potassium and increased
risk of stroke. Increasing dietary potassium has lowered blood pressure
in humans, which by itself should reduce the risk of stroke. However,
some of the protective effect of potassium appears to extend beyond
its ability to lower blood pressure. Maintaining a high potassium
intake is best achieved by eating fruits and vegetables.
A diet high in the
omega-3 polyunsaturated fatty acids has been shown to lower the
risk of strokes in several studies. Eating fish, naturally high
in these fatty acids, has been shown to reduce strokes, and even
some of the risk factors associated with strokes such as high blood
pressure.
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Nutritional
Factors Shown to be Beneficial
Vinpocetine
Vinpocetine is a powerful antioxidant. This function, coupled with
its ability to increase the flexibility of red blood cells, further
enhances blood flow to damaged brain areas while reducing the risk
of subsequent stroke.
Dose: 5 mg twice a day
B Vitamins
Homocysteine reducing agents
Higher blood levels of vitamin B6, vitamin B12, folic acid and betaine
(trimethylglycine) are associated with low levels of homocysteine,
a risk factor for stroke. Deficiencies any of these vitamins can
high levels of homocysteine. These nutrients are best taken together
to reduce homocysteine, as even though they act differently they
all interact with homocysteine or one of its metabolites
Dose: Folic acid 2.5 mg / day
Dose: Vitamin B6 25 mg / day
Dose: Vitamin B12 250 mcg / day
Dose: Betaine 3-6 g/ day
Omega-3
Fish Oils
Fish oils consist of omega 3 fatty acids that improve blood flow,
and have been shown to reduce the damage to neurones caused by an
ischemic stroke.
Dose: range from 3-5 grams a day.
Nicotinamide
adenine dinucleotide (NADH)
NADH is a form a vitamin B3 that plays an essential role in the
energy production of every human cell. It may help to revitalize
damaged neurons.
Dose: 5 mg twice a day
Coenzyme
Q10 (CoQ-10)
CoQ10, when given preventatively, has shown to decrease the risk
of any neurological defects in controlled studies. It is also a
potent brain antioxidant.
Dose: 150-200 mg a day
Magnesium
Researchers have found an association between diets low in magnesium
and decreased risk of stroke, an effect explained partially, but
not completely, by the ability of magnesium to reduce high blood
pressure.
Dose: 400- 800 mg a day
Vitamin
E
Vitamin E is a general term for a chemical class known as the tocopherols
and tocotrienols. Vitamin E can reduce heart disease risk factors
for stroke.
Dose: 400-800 IU a day
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Recommended
NaturalMeds Products for Stroke
Brain
Sustain Powder
BrainSustain is a powdered supplement that contains N-acetyl cysteine,
phosphatidylserine, acetyl-l-carnitine, coenenzyme Q 10, and ginkgo
extract in a great tasting drink. It also contain nutrients such
as vitamin C, D and E; the minerals calcium, magnesium and potassium.
It comes in a whey or rice protein. It is specifically formulated
to enhance brain performance and promote brain health.
Dose: 2 scoops (25 g) a day Pack size: Whey
powder -330 grams; Rice powder- 600 g
Neuroactives
Made by the makes of BrainSustain, Neuroactives is a capsule alternative.
It contains N-acetyl cysteine, phosphatidylserine, acetyl-l-carnitine,
coenzyme Q 10, and ginkgo extract, but without the extra vitamins.
This product is useful for someone already one a multivitamin.
Dose: 2 capsules twice a day Pack size: 60
capsules
Omega
3
Omega-3 Formula provides an excellent source of Omega-3 fatty acids
in their naturally existing ratios. This ratio provides the fatty
acids EPA and DHA in balanced amount to promote cardiac health.
Dose: 2 capsules Pack size: 60 capsules
EPA
This particular formula is highly concentrated in EPA, having 850
mg per capsule. It also contains 200 mg of DHA.
Dose: 2 capsules Pack size 60 capsules
Vitamin
E Mixed tocopherols 400 IUs
Vitamin E is a fat-soluble vitamin that is one of the body's chief
antioxidants, helping to protect cell membranes against oxidation.
This product has the addition of mixed tocopherols, of which Vitamin
E is related.
Dose: 2 softgels with food times a day Pack
size: 50 softgels
CoQ10
30 mg
Coenzyme Q10 is essential to human life. It plays a role in energy
production cycles that converts food into energy. Research indicates
that supplementation with this nutrient may support normal heart
function, and provide antioxidant protection. It is best taken with
food, especially with a food that contains fat as it improves absorption.
Dose: 5 capsules with meals a day Pack size:
30 and 100 capsules
Magnesium
Malate 625 mg
Magnesium is an essential mineral, playing a key role in over 300
enzymatic reactions in metabolism. It relaxes muscle tissues, including
helping to relax the vessels of the heart to reduce spasm. Magnesium
malate has the high absorption rate of any form.
Dose: 1-2 capsules a day with food Pack size:
XXX
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