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What is Stroke

Diagnosis and Pharmaceutical Interventions

Lifestyle and Dietary Modifications

Nutritional Factors Shown to be Beneficial

Recommended NaturalMeds Products for Stroke


Printable Version

Stroke

A stroke or cerebrovascular accident (CVA) occurs when brain tissue is damaged. This can occur two different ways. In an ischemic stroke one of the arteries in the brain becomes blocked. When this happens, part of the brain tissue does not receive the flow of blood it needs to function and survive. The death of that tissue is the result. This type is more common. Or, in a hemorrhagic stroke one of the arteries in the brain leaks or bursts. The blood seeps into the brain tissue. As a result, the affected brain tissue dies. A transient ischemic attack (TIA) is a temporary or mini stroke of the ischemic type. TIAs result when there is a temporary disruption in blood flow to the brain tissue. TIAs are extremely important warning signs for stroke and should not be ignored. Most ischemic strokes and TIA’s are a result of atherosclerosis, or plaques, in the carotid artery, the main artery to the brain.

In western countries, stroke is a leading cause of death, and is the second most common neurological disorder after Alzheimer’s disease. In the United States, stroke is the third leading cause of death, despite a general decline in the incidence of stroke in the last 30 years.

Stroke rates increase in a stepwise fashion with age. Tobacco use imparts a significant risk of stroke that is correlated to usage. Heavy smokers have twice the relative risk of stroke compared to light smokers, and the risk of stroke is significantly reduced within 2 years of smoking cessation, with a return to baseline at 5 years. Hypertension and systolic blood pressure, diabetes, male gender, and high cholesterol are additional risk factors that have been shown to impart an elevated risk of stroke. Similar to recent work in the study of heart disease, inflammation has been shown to be associated with an increased risk of carotid atherosclerosis. Increased awareness of other risk factors (heart disease, AIDS, recreational drug abuse, heavy alcohol consumption, family history of stroke) has reduced the incidence of strokes. Elevation of the blood homocysteine level is also a risk factor for stroke. A previous stroke makes individual patients more susceptible to further strokes.

Symptoms
The clinical presentation of stroke is often subtle and varied. Onset is usually sudden. Often there will problems with movement on one side of the body, starting at one point such as an arm and travelling to other areas. Problems with speech are usually the most obvious signs. Dysarthria is a disturbance in articulation of speech and is caused by paralysis or incoordination of muscles used for speech. Dysarthric speech is often slurred. Repetition of simple phrases may identify subtle cases. In contrast, aphasia is caused by a disturbance in processing language (either written or spoken) and can be receptive (difficulty in comprehension), expressive (difficulty in communicating thoughts), or both. Both can happen. Confusion, vertigo, problems with vision may occur, with weakness. Concomitant complaints such as headache, vomiting, or recent trauma may be present. Symptoms of TIA’s may last from seconds to minutes, and then no after effects are noticed.
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Diagnosis and Pharmaceutical Interventions

There are several methods of helping to make the diagnosis of a stroke or TIA. A very specific neurological examination performed by the health care practitioner can help to locate which part of the brain that is affected. The basic neurologic assessment can be broken down into six major areas:

  1. level of consciousness
  2. visual assessment
  3. motor function
  4. sensation and neglect
  5. cerebellar function
  6. cranial nerves

Many of these tests may seem rather silly, such as walking on the tip toes, but each has a specific function. Imaging studies may also be used, as a CT (computerized tomography) can differentiate bleeding inside the brain from ischemia. Evaluation of heart function is usually administered as well, to identify a heart attack. Blood tests that may be helpful include a complete blood count with platelet count, coagulation studies, and toxicologic screen. A toxicologic screen for cocaine or amphetamine use should be obtained in patients with either ischemic or hemorrhagic stroke in which substance abuse is suspected, particularly young adults with stroke.

When a diagnosis of a stroke has been made medications are usually initiated right away. Anticoagulation drugs that increase the flow of the blood to the areas of the brain (when the condition is not caused by a haemorrhage) can reduce the incidence of long term neurological damage. If the stoke has caused a loss of consciousness, medications may need to be given by IV, as well as the basics such as fluids and electrolytes. Long term management usually includes some form of anticoagulation therapy, such as taking a small amount of aspirin, a known blood thinner, every day.

Hemorrhagic stroke must be identified before therapy is given as agents that thin the blood are contraindicated. Surgery may be necessary in those cases.
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Lifestyle and Dietary modifications

Exercise reduces the risk of stroke according to most studies. The benefits of exercise are probably due to its effects on body weight, blood pressure, and helping to maintain a healthy blood sugar. It also reduces obesity, which has been shown to increase risk of stroke in most studies. Excess abdominal fat (central obesity) appears to be more directly linked to increased risk of stroke, compared with fat accumulation in the thighs and buttocks. While losing weight and keeping it off is difficult for most people, normalizing weight with a healthful diet and exercise program is one of the best ways to reduce the risk of many diseases, including stroke.

Having one or two drinks per day has lowered stroke risk in most studies, but some believe that even light drinking leads to an increased risk of stroke. Regular heavy drinking or binge drinking, however, has consistently raised the risk of suffering a stroke by increasing blood pressure and causing heart muscle abnormalities and other effects.
Smoking is associated with a significantly increased risk of stroke. Even secondhand smoke puts non-smokers at increased risk.

Diets high in fruit and/or vegetables are associated with a reduced risk of stroke, according to most studies. In a large preliminary study, cruciferous and green leafy vegetables, as well as citrus fruit and juice, conferred the highest degree of protection. Because it is not clear which components of fruits and vegetables are most responsible for the protective effect against stroke, people wishing to reduce their risk of stroke should rely primarily on eating more fruits and vegetables themselves, and having a healthy diet, rather than taking supplements. There is an association between diets low in potassium and increased risk of stroke. Increasing dietary potassium has lowered blood pressure in humans, which by itself should reduce the risk of stroke. However, some of the protective effect of potassium appears to extend beyond its ability to lower blood pressure. Maintaining a high potassium intake is best achieved by eating fruits and vegetables.

A diet high in the omega-3 polyunsaturated fatty acids has been shown to lower the risk of strokes in several studies. Eating fish, naturally high in these fatty acids, has been shown to reduce strokes, and even some of the risk factors associated with strokes such as high blood pressure.
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Nutritional Factors Shown to be Beneficial

Vinpocetine
Vinpocetine is a powerful antioxidant. This function, coupled with its ability to increase the flexibility of red blood cells, further enhances blood flow to damaged brain areas while reducing the risk of subsequent stroke.
Dose: 5 mg twice a day

B Vitamins Homocysteine reducing agents
Higher blood levels of vitamin B6, vitamin B12, folic acid and betaine (trimethylglycine) are associated with low levels of homocysteine, a risk factor for stroke. Deficiencies any of these vitamins can high levels of homocysteine. These nutrients are best taken together to reduce homocysteine, as even though they act differently they all interact with homocysteine or one of its metabolites
Dose: Folic acid 2.5 mg / day
Dose: Vitamin B6 25 mg / day
Dose: Vitamin B12 250 mcg / day
Dose: Betaine 3-6 g/ day

Omega-3 Fish Oils
Fish oils consist of omega 3 fatty acids that improve blood flow, and have been shown to reduce the damage to neurones caused by an ischemic stroke.
Dose: range from 3-5 grams a day.

Nicotinamide adenine dinucleotide (NADH)
NADH is a form a vitamin B3 that plays an essential role in the energy production of every human cell. It may help to revitalize damaged neurons.
Dose: 5 mg twice a day

Coenzyme Q10 (CoQ-10)
CoQ10, when given preventatively, has shown to decrease the risk of any neurological defects in controlled studies. It is also a potent brain antioxidant.
Dose: 150-200 mg a day

Magnesium
Researchers have found an association between diets low in magnesium and decreased risk of stroke, an effect explained partially, but not completely, by the ability of magnesium to reduce high blood pressure.
Dose: 400- 800 mg a day

Vitamin E
Vitamin E is a general term for a chemical class known as the tocopherols and tocotrienols. Vitamin E can reduce heart disease risk factors for stroke.
Dose: 400-800 IU a day
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Recommended NaturalMeds Products for Stroke

Brain Sustain Powder
BrainSustain is a powdered supplement that contains N-acetyl cysteine, phosphatidylserine, acetyl-l-carnitine, coenenzyme Q 10, and ginkgo extract in a great tasting drink. It also contain nutrients such as vitamin C, D and E; the minerals calcium, magnesium and potassium. It comes in a whey or rice protein. It is specifically formulated to enhance brain performance and promote brain health.
Dose: 2 scoops (25 g) a day Pack size: Whey powder -330 grams; Rice powder- 600 g

Neuroactives
Made by the makes of BrainSustain, Neuroactives is a capsule alternative. It contains N-acetyl cysteine, phosphatidylserine, acetyl-l-carnitine, coenzyme Q 10, and ginkgo extract, but without the extra vitamins. This product is useful for someone already one a multivitamin.
Dose: 2 capsules twice a day Pack size: 60 capsules

Omega 3
Omega-3 Formula provides an excellent source of Omega-3 fatty acids in their naturally existing ratios. This ratio provides the fatty acids EPA and DHA in balanced amount to promote cardiac health.
Dose: 2 capsules Pack size: 60 capsules

EPA
This particular formula is highly concentrated in EPA, having 850 mg per capsule. It also contains 200 mg of DHA.
Dose: 2 capsules Pack size 60 capsules

Vitamin E Mixed tocopherols 400 IUs
Vitamin E is a fat-soluble vitamin that is one of the body's chief antioxidants, helping to protect cell membranes against oxidation. This product has the addition of mixed tocopherols, of which Vitamin E is related.
Dose: 2 softgels with food times a day Pack size: 50 softgels

CoQ10 30 mg
Coenzyme Q10 is essential to human life. It plays a role in energy production cycles that converts food into energy. Research indicates that supplementation with this nutrient may support normal heart function, and provide antioxidant protection. It is best taken with food, especially with a food that contains fat as it improves absorption.
Dose: 5 capsules with meals a day Pack size: 30 and 100 capsules

Magnesium Malate 625 mg
Magnesium is an essential mineral, playing a key role in over 300 enzymatic reactions in metabolism. It relaxes muscle tissues, including helping to relax the vessels of the heart to reduce spasm. Magnesium malate has the high absorption rate of any form.
Dose: 1-2 capsules a day with food Pack size: XXX

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