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What
is Chronic Fatigue Syndrome
The disorder we
call chronic fatigue syndrome (CFS) does not appear to be new. It
is a condition in which is characterized by muscle pain and weakness,
with extreme fatigue that is prolonged after events such as exercise.
It is usually coupled with symptoms associated with infection, such
as sore throat, mild fever and enlarged tender lymph nodes.
The cause of CFS
is controversial. Psychological factors may be the cause in some;
however, chronic fatigue syndrome appears to be distinct from typical
depression, anxiety, or other psychological disorders. A chronic
viral infection has been proposed because many patients relate onset
to an event similar to influenza or mononucleosis. Epstein-Barr
virus is a possible cause, but the markers of exposure to the virus
are not sensitive to show a specific causation.
The prevalence is
impossible to state with precision, varying from 7 to 38 cases/100,000
population. This variation may be due to differences in psychologic
or genetic makeup, social acceptability, or exposure to an infectious
or toxic agent or to differences in diagnosing. Women are affected
1.3 to 1.7 times more often than men. Chronic Fatigue Syndrome primarily
afflicts Caucasian women between the ages 25 and 45
Allergic reactions
have also been proposed as the aetiology; about 65% of patients
complain of previous allergies, and for them, the rate of cutaneous
reactivity to inhalants or foods is 25 to 50% higher than that in
the general population.
Typically, CFS arises
suddenly in a previously active individual. An otherwise unremarkable
flu-like illness or some other acute stress leaves unbearable exhaustion
in its wake. Other symptoms, such as headache, sore throat, tender
lymph nodes, muscle and joint aches, and frequent feverishness,
lead to the belief that an infection persists, and medical attention
is sought. Over several weeks, despite reassurances that nothing
serious is wrong, the symptoms persist and other features of the
syndrome become evident—disturbed sleep, difficulty in concentration,
and depression.
Many patients report
that diverse complaints are linked—that during periods of
greatest fatigue they perceive the most pain and difficulty with
concentration. Patients also commonly assert that excessive physical
or emotional stress may exacerbate their symptoms.
Symptoms
of CFS
The
main symptom is severe fatigue, generally longer than 6 months,
which impairs daily life and is often made worse by exertion, exercise,
headache, sore throat, and other stresses. It may be accompanied
by enlarged, painful lymph nodes; sore throat; headache; joint pain;
abdominal pain; muscle pain; low-grade fever; and cognitive difficulty,
especially difficulty concentrating and sleeping. Many patients
relate symptom onset to a viral-like syndrome, with swollen glands,
extreme fatigue, fever, and upper respiratory symptoms.
Mild to moderate
depression is present in half to two-thirds of people. Much of this
depression may be reactive to the health situation, but its prevalence
exceeds that seen in other chronic medical illnesses.
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Diagnosis
and Pharmaceutical Interventions
Because the cause
is unknown, diagnostic evaluation aims to exclude conditions which
may have a distinct cause and treatment first. A reasonable assessment
includes looking at blood cell values and chemistries, and evaluation
of some hormones such as thyroid. In some cases, and tests for antinuclear
antibody, rheumatoid factor, Lyme disease antibody, hepatitis A
or B antibodies, and HIV antibody should be added.
Pharmaceutical
Medications
Treatment
for CFS is needs to be individualised, geared towards reducing pain
with making the fatigue worse. Non-steroidal anti-inflammatory drugs
(NSAID’s) alleviate headache, diffuse pain, and feverishness.
NSAID’s include over the counter medications like aspirin,
ibuprofen, panadol as well as prescription medications like celebrex,
and voltaren. NSAIDS can cause bleeding ulcers in the stomach, and
may interfere with normal bleeding times.
Antidepressants
appear to be the most successful treatment studied so far; as many
as 80% of patients report benefit. Non-sedating antidepressants
improve mood and disordered sleep and may attenuate the fatigue.
However, a host of potential side-effects (or symptoms of withdrawal)
accompany the use of many antidepressants. Some of the most serious
of these are: anxiety, asthenia – loss of bodily strength,
blurred vision, constipation , decreased ability to think clearly,
development of drug dependency, development or worsening of suicidal
tendencies, dizziness, dry mouth, insomnia , loss of libido and
other sexual side effects, nausea, nervousness, rash , somnolence
– sleepiness or a lack of energy and activity, and sustained
increase in blood pressure (hypertension).
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Lifestyle
and Dietary Modifications
Exercise is important
to prevent the worsening of fatigue. Many people report feeling
better after undertaking a moderate exercise plan. However, most
people with CFS are sensitive to overexertion, and excessive exercise
may lead to consistently worsening fatigue and mental functioning.
Exercise should be attempted gradually, starting with very small
efforts. Intermittent exercise, in which patients walked for three
minutes followed by three minutes of rest for a total of 30 minutes,
usually does not create fatigue or make symptoms worse.
Eating a whole foods
based vegan diet may improve body pain in some pain syndromes, including
CFS. A vegan diet excludes all animal products, and increases the
amount of vegetables and fruits, which are high in antioxidants.
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Nutritional
Factors Shown to be Beneficial
Magnesium
Magnesium is an essential mineral needed for proper muscle relaxation.
Levels may be levels low in CFS sufferers. Magnesium that is bound
to an organic compound called malic acid is absorbed form the body
in higher amounts and may have an effect in reducing the pain of
CFS.
Dose: 200-300 mg three times day.
B
vitamin complex
Some people with CFS have reduced B-vitamin status when compared
to people without the condition. B Vitamins are involved in many
metabolitic processes in the body, including energy producing reactions.
Dose: B vitamin complex, 50 mg a day
L Carnitine
L-carnitine is required for energy production, and is extensively
used by cells in muscle tissue. Deficiencies of carnitine are common
in some CFS sufferers.
Dose: 1 gram of carnitine a day
Omega 3
Fish Oil
Low levels of essential fatty acids (EFAs) appear to be a common
finding in chronic fatigue syndrome. With supplementation symptoms
including fatigue, depression, aches and pains, showed a significantly
greater improvement.
Dose: 2-6 grams a day
Vitamin
C
Depression is the first symptom of experimentally induced scurvy,
the condition caused by vitamin C deficiency. Supplementing with
Vitamin C produces an analgesic effect, as well as improves the
immune response.
Dose: 3-6 grams a day
5-Hydroxytryptophan
(5-HTP)
CFS suffers may have low levels of tryptophan, the dietary precursor
of serotonin. 5-HTP, a metabolite of tryptophan and immediate precursor
of serotonin may offer improvement in fatigue, pain intensity, anxiety,
and sleep quality.
Dose: 50-300 mg three times a day
CoQ-10
CoQ-10 improves the energy of the cell. With supplementation, people
with CFS may show improved exercise tolerance.
Dose: 30 -100 mg a day
Eleuthero
(Eleuthrococcus senticosus)
Eleuthero, also called Siberian ginseng, is an adaptogenic herb.
It may be useful for CFS patients—the herb not only has an
immunomodulating effect but also helps support the normal function
of the hormonal stress system of the body.
Dose: 300- 400 mg a day of the standardized
extract
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Recommended
NaturalMeds Products for CFS
Magnesium
Malate 625 mg
Magnesium is an essential mineral, playing a key role in over 300
enzymatic reactions in metabolism. It relaxes muscle tissues, and
has been used in the treatment of chronic pain. Magnesium malate
has the high absorption rate of any form.
Dose: 1-2 capsules a day with food Pack size:
XXX
B
Vitamin Complex 50
B vitamins are used for the production of energy. Each B vitamin
fills a different, complementary need, which is why they should
most often be taken together.
Dose: 1-2 tablets a day Pack size: 50 tablets
CoQ10
30 mg
Coenzyme Q10 is essential to human life. It plays a role in energy
production cycles that converts food into energy. Research indicates
that supplementation with this nutrient may support normal health
and provide antioxidant protection. It is best taken with food,
especially with a food that contains fat as it improves absorption.
Dose: 3 capsules with meals a day Pack size:
30 and 60 capsules
5-HTP
50 mg
Studies have shown that 5-HTP increases the amount and availability
of serotonin, a neurotransmitter, produced by the body.
Dose: begin with 1 capsule, gradually increasing
dosage up to two capsules daily, if needed, three times a day, away
from food Pack size: 30 tablets
Vitamin
C Ascorbic acid crystals
Vitamin is an astounding nutrient, as supplementation not only helps
with immune function but as an antioxidant protects against free
radical damage that may cause fatigue and contribute to disease.
Powdered forms of vitamin C are easy to take.
Dose: ½ teaspoon two to threes times
a day Pack size: 8 ounces (226.796 g)
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